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KMID : 0616120160470020103
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Korean Journal of Pharmacognosy
2016 Volume.47 No. 2 p.103 ~ p.109
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Immunoaugmenting Activity of Acemannan, the Polysaccharides Isolated from Aloe vera Gel
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Im Sun-A
Park Chan-Su
Lee Chong-Kil
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Abstract
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Aloe vera L.(Aloe barbadensis Miller) has been used for many centuries for various medical, cosmetic and neutraceutical purposes. The gel of A. vera was reported to exert numerous biological activities including wound healing, immunomodulatory, anti-cancer, anti-inflammatory, anti-bacterial, anti-viral, anti-diabetic, and anti-psoriasis activities. Acemannan, found predominantly in the inner leaf gel of A. vera, has been identified as the main active ingredient exerting diverse biological activities. In this review, we summarized the recent findings on the immunomodulatory activities of acemannan. Studies that used purified acemannan demonstrate that acemannan exerts immune-stimulating, anti-cancer, anti-viral, and hematopoiesis-increasing activities. In addition, it is being clear that most of these activities of acemannan are mediated primarily by activating professional antigen presenting cells such as macrophages and dendritic cells.
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KEYWORD
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Aloe vera , Acemannan , Immunomodulation , Anti-cancer activity , Anti-viral activity , Hematopoiesis
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